In mixing sterile preparations, the following things need to be considered: protection of products from microorganism contamination, protection of personnel and the environment from exposure, stability of preparations, and non-mixing of preparations. Therefore, to avoid unwanted things, the handling of preparations must be carried out in a special room (sterile), in a disciplined, careful manner and adequate knowledge and skills are needed to prevent unwanted risks. This guidebook is expected to be a reference for pharmacists in dispensing sterile preparations.